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This question was answered on Wed 06, Aug 2008 10:57pm by Dr Paul S, MD

Bilateral mastectomy having had bilateral microcalcifications . Biopsy with atypical ductal hyperplasia


    
Asked by user (Female; 60; 60 Year old female with history of breast cancer in maternal affiliation.; Relevant drugs:Your opinion on this matter is in no way related to legal matters. It is for personal use only. Want to know in plain terms if bilateral mastectomy was needed as there was no chemo or radiation ordered. Could ths have possibly been treated with say a lumpectomy? Does the hyperplasia mean that in time it would have become a mailignant carcinoma? ) on Tue 05, Aug 2008 02:23am
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A. The pathology report reads as such: L Breast, Simple Mastectomy 1. Benign breast tissue with : a:Mild Fibrocystic change with occasional microcalcifications b: focal ductal epithelial hyperplasia of the usual type 2. Benign nipple and skin with small capillary hemangioma. B. Lymph node sentinel node "a" excision: one benign lymph node with no carcinoma (0/1)see comment C. Lymph node sentinel node "b" excision: one benign lymph node with no carcinoma (0/1) see comment D. Lymph node right axillary excision : one benign lymph node with no carcinoma (0/1) E. Breast Right Modified Radical mastectomy: 1. Breast Tissue with : a. Focal lobular involvement by atypical cells (see comment) b. No residual invasive carcinoma identified c. Prior biopsy site changes d. Fibrocystic change with occasional microcalcifications e. Mild ductal epithelial hyperplasia of the usual type and focal columnar cell change/ hyperplasia 2. Benign skin with scar, capillary hemangioma and intradermal nevus. 3. Benign nipple with capillary hemangioma Lymph nodes right axillary excision two benign lymph nodes with no carcinoma (0/2) Comment: Immunohistochemistry for pan-cytokeratin, KC3, is performed on sections of both sentinel lymph nodes (blocks B and C) with appropriately reactive controls. No mestastic carcinoma is noted by both H and E . Three additional benign lymph nodes are identified with no metastastic carcinoma. Slide E5 a section from outer quadreants shows rare lobular involvement by atypical cells with similar cytology as the carcinoma seen in original tumor. No invasive carcinoma is present.

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Answer by Dr Paul S, MD  on Wed 06, Aug 2008 10:57pm:

Hi. I'm assuming that the biopsy that you had earlier in your right breast revealed invasive cancer. The decision to do lumpectomy is dependent on a several factors, and the most important would be the size of the primary tumor. Tumors less than 5 cm, or with no other satellite lesions are amenable to lumpectomy. However, if the initial histology is an invasive lobular cancer, then it is indeed risky to perform a lumpectomy since these types of tumors tend to have non-discrete borders, and may also occur bilaterally (in the other breast as well). The decision to do a bilateral mastectomy may have depended on two reasons. One is that the histology of lobular cancer has a tendency to occur bilaterally and therefore, bilateral mastectomy may be justified. The second is that the over all assessment of your doctor is that you really have a high risk of developing breast cancer on the other breast and the bilateral mastectomy is aimed to reduce this risk. The atypical hyperplasia is the one which can eventually develop into cancer, which was already removed during the surgery. Regards.

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