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This question was answered on Fri 21, Mar 2008 09:34pm by Dr Fernando, MD

Breaast Cancer - Pathology report shows two small tubular proliferations


    
Asked by tarzetta (Male ) on Fri 21, Mar 2008 09:52am

This is the comment on my pathology report: My index of suspicion that the two small tubular proliferations repressent low grade carcinoma is high. There is also a separate small focus of atypical ductal hyperplasia. Excision is recommended. Given the high index of suspicion, sentinel lymph node biopsy would not be inappropriate. Deeper levels were obtained from both tissue blocks (a total of 16 levels were examined from each block) Final Diagnosis: Breast, right at 12:00, 16-Guage Core Biopsies: Two small foci of atypical tubular proliferation. Atypical ductal hyperplasia. Do I have breast Cancer?
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Answer by Dr Fernando, MD  on Fri 21, Mar 2008 09:34pm:

Hi, Atypical ductal hyperplasia is what is called a "pre-malignant" condition. This means that with time, patients having this condition eventually progress into outright carcinoma. So having this condition alone may already warrant excision of the lump or lesion. However, this is not the only finding that the pathologist was concerned about. He mentions "two small tubular proliferations" with a high probability of low grade carcinoma. Since the pathologist who originally read this slide is not sure of his finding, it might be prudent to have it reviewed by another pathologist, because there is a possibility that those tubular proliferations are indeed, cancer, albeit of a low grade variety (probably carcinoma in situ). If a diagnosis of cancer is confirmed on slide review by another pathologist, then the sentinel lymph node biopsy would become the appropriate next step.

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Comment by tarzetta on Sat 22, Mar 2008 11:15am: Thank you so much for the answer. It was reviewed by two pathologists. They agreed on the finding. However, my OBGYN doctor has made me an appointment with a surgeon for Tuesday, March 27. These are great surgeons in a great group. I have many friends who have used them who have had breast cancer. I will know more on Tuesday. What is carcinoma in situ?
Comment by tarzetta on Mon 24, Mar 2008 08:08am: My OBGYN doctor has made me an appointment with a surgeon for Tuesday, March 25, 2008. I should know more after I meet with my surgeon. I have a friend who has had breast cancer, masectomy, and chemo who will be going with me. I feel really comfortable with her going with me in that she knows the questions to ask. I have my film to take with him, and also, they have sent to him my pathology report.
Comment by Dr Fernando, MD on Fri 28, Mar 2008 05:32pm: Hi, I'm glad you have a friend who understands what you're going through and who is willing to give much needed support. As for your other question, carcinoma in situ is a form of breast cancer which is confined within the ducts of the breast glands and has not penetrated or invaded through the glands. It is sometimes referred to as "Stage 0" disease, to indicate that it is the earliest and least advanced form of the disease.

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