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This question was answered on Wed 06, May 2009 08:26am by Dr. Monica, MD

Cervical Cancer? Need Diagnosis


    
Asked by anghelson (Female; 26; Appendectomy (when I was about 11yrs old) 3X ceasarian section (1998, 2001, 2003) Subtotal hysterectomy (2005) Left oophorectomy (2007) ) on Tue 05, May 2009 04:38pm
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latest TVS(3/23/09)=liver-mild hepatomegaly w/ fatty infiltration. gall blader 3 sml gallstones. cervical remnant showing a large lobular anechoic structure (15.9mm posterior upper segment), a smaller nodule of 4.8mm noted superiorly. Right overy sml low echogenicity foci are noted. now after intercourse brownish vaginal discharge, on stool always have red blood. cause of hysterectomy MISDIAGNOSIS, said that total but cervix was left behind. lower right pelvic pain started 10/7/06. 1st tvs structure noted w/in lower pelvic cavity showng multiple sml anechoic 6.8mm, 2nd tvs 10/22/08 normal size cervix w/ unilocular cystic structure w/ irregular thicked border 1.5x1.4cm. (-)minimal free fluid in the cul de sac. suffering pain for almost 4yrs and getting severe. is it cervical cancer? new doctor said it might be. I also have right lower back pain that radiates to my right leg, everyday i always feel so tired. every time I go to the bathroom afterwards i become very dizzy, i have a number of bruises in parts of the body. sometimes i have difficulty in breathing. thank you. pls help me

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Answer by Dr. Monica, MD  on Wed 06, May 2009 08:26am:

Hi, You have had a subtotal hysterectomy in 2005 and a left sided oophorectomy in 2007. It would be helpful to know the indication for the hysterectomy and the oophorectomy. You have not specified those. The tissues removed during the surgeries would have been subjected to a pathological assessment. It would be helpful if you provide those details too. The left side oophorectomy would presumably have been done for an ovarian mass or cyst. The histopathology report on the ovarian tissue would provide the details regarding the nature of the lesion. Currently, you have multiple lesions in the cervical remnant and the right ovary. The brownish vaginal discharge is most likely due to the mass in the cervial stump. Red blood in the stools indicates bleeding arising from the rectum, anal canal or lower part of the large intestine. The low back pain radiating to the leg can be caused by the cervical mass. Your dizziness can be due to anemia caused by the prolonged bleeding. Multiple bruises over the body suggest a problem with blood clotting. Occassional difficulty in breathing may be related to the anemia but can have many other causes. You need to undergo a thorough medical examination and further investigations which would include a gynecological checkup, a proctosigmoidoscopy which is an endoscopic evaluation of the anal canal, rectum and lower large bowel, complete blood counts, some biochemical tests to evaluate the liver and renal status, a chest radiograph, ECG and a CT scan and MRI of the pelvis. A diagnosis of cancer can only be established or ruled out by taking a biopsy or an FNAC from the suspicious mass. It is important that you do not delay your examination and investigations but please do not panic. The diagnosis can be established once these preliminary investigations are done and then the treatment options and prognosis can be discussed. All the best and God Bless!

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Follow up:

Clarification by anghelson on Wed 06, May 2009 11:17pm:
Hi, thank you very much for having time to answer me. Im reall am so greatful from the bottom of my heart.
   you have ask me to provide the Histopathology report of the overy and the pathological assesment of the
hysterectomy. I just want warn you 1st of the pathology report that we think is not truthful, unfortunately we
were surprise to found out that the pathology was done in a mental institution very far from our place and the
doctor herself that had done the procedure took it there (hosp. where the procedure was done has a lab for
that). 
    june 14,2005 in the evening I bleed a little heavy, me not knowing that my contraceptive I was
taking(depo-proveda) will cause irregular menstration, & that sometimes heavy or very little, bbut my
husband became concerned(not knowing that it will really be like that) took me the following day to my OB.
When i arrived there and told her about the bleeding w/out any pregnancy test done she told me that its
eptopic pregnancy and needs raspa(cleaning, not surgery) but 1st I argued that i cannot be pregnant because of
depo-proveda which was on the 2nd month. anyway because that was her order i went to hosp. to get raspa, they
did not even gave me general anesthesia just gave me regional. then she told me that she has to measure my
uterus then thats the time all of them panic i had severe bleeding that she even opened me up without
anesthesia in my abdomen. I woke up in the ICU. I learned I had cardiac arrest, I had 11 bags of blood
transfusion,  my platelets went so down they need to fix my bladder & they did total hysterectomy. I ask
what caused all this PLACENTA PREVIA ACCRETA.I had 2 catheters and went home still with one. then afetr 4
mnths my lower right started to have pain, she just told me its gas pain. But my pain gets more severe so I
reapetredly insisted her to have an ultrasound that was october of 2005 where they saw that my 2 overies has a
cysts. The cysts in my right overy was bigger than my cyst in the left that on jan.2007 the left ovary twisted
and ruptured. I were thinking that why did she still had not remove the other overy that it may cause also
twist and rupture, but she explained that I would age faster (I was 23 that time). But after a few weeks the
pain came back & every I kept on complaining to her & to give me explaination of whats causing it. She
always just say gas pain so we decided to go to the advance city of my country (we live in a province) and it
was also the time i had my 1st siezure. when i went already to manila there i found out that only a subtotal
hysterectomy was done, and i was diagnose of epelepsy tonic clonic siezure (now controlled). now only my
neurologist accepted me so my siezure was controlled but when we go to an ob- gyn they do not want to accept
me because of so many reasons. the ultrasound reports that i told you, I was the only one who decided to have
it done. Thats why i am asking for your help. I am in so my pain, our lives is never been desame. we are
already spending a lot just to have treatment. I hope you can help me. I went to my friends ob-gyn &
pleaded her to just give me explaination and she have me go to an oncologist after reading all my results.Ill
send you in my histopath and pathology result in a little while just copying it. again my family and I thank
you
Clarification by anghelson on Thu 07, May 2009 12:20am:
HISTOPATHOLOGY
Specimen: Left Ovary and Fallopian tube
PathologicDiagnosis:
	Left Ovary: SEROUS CYST WITH HEMORRAGE AND FOCAL AREAS OF INFARCTION
	Left Fallopian Tube: CONGESTION
GROSS AND MICROSCOPIC FINDINGS:
	The specimen consist of a cystic ovary labeled left and measuring 9.0x8.0x4.0cm in its collapsed state.
Sections show a unilocular cyst containing clear serous fluid. The cyst wall measures 0.1 to 0.2 cm in
thickness. No solid areas are noted. The fallopian tube measures 6x0.5x0.5cm. Representative sections taken
	Microscopic of disclose ovarian cyst lined by a layer of low cuboidal to flattened cells.  The cyst wall is
fibrocollagenous. Focal areas of infraction and hemorrhages are noted. The fallopian tube shows moderate
congestion.
Surgical Pathologigy Report
Clinical Impression:  Placenta percreta
Specimen: Uterus
Procedure TAH
Gross Description
	The specimen submitted consist of a uterus with detached lower uterine segment. The uterine corpus measures
7.0x8.0x5.5cm and appears brownish and ovoid. Cut sections reveal a 3.0cm thick myometrium and a pinkish red
endometrial layer. Three detached fragments are also submitted. The first appears grayish, irregular, and
doughy, measuring 4.0x3.0x2.5cm.RSEB7
Microscpic Description
	Sections of the uterus reveal gravid uterine changes exemplified by decidualization of the endometrium and
hypertrophy of the myometrium. Sections of the lower uterine segment as well as the three detached tissue
fragments reveal presence of chronic villi, some with myxoid degeneration, on and within the upper layer of
the myometrium without an apparent decidual plane.
Diagnosis: Uterus, TAh = post-gravid uterine changes =c/w placenta accreta
 

Clarification by anghelson on Thu 07, May 2009 11:01am:
thank you for explaining clearly the reasons about not removing the other overy and I understand. Yes they did
a transvaginal ultrasound that very day of my operation. it was stated in the report that rule out accreta.
The one that did the ultrasound is also one of the doctors that made the surgical procedure. I really would
like to know your personal opinion espaecially with the large lobular structure and smaller nodule seen in my
cervix, can it may be a sign of becoming cancer? it would really be helpful to me because i could plan for the
next step like how to get it cured, but i will still do all the checkups and evaulation you have advice. but I
really like to know.. I think today after reading your fierst answer not less than 25 times i keep on coming
back to check if you have replied. again thank you from me and my family, may god be the one to repay you w/
blessings. ill be waiting for your opinion. thankx 

Comments:

Comment by Dr. Monica, MD on Thu 07, May 2009 08:31am: Hi, Thank you for sending your pathology reports and providing more details. The chances of getting pregnant while on Depo-Provera are very less but a remote possibility exists. A urine pregnancy test or serum Beta-HCG levels can indicate pregnancy, but it has to be confirmed on ultrasound examination. A diagnosis of "Ectopic pregnancy" and "Placenta Previa Accreta" can only be made on ultrasound examination. Did you doctor order these test before subjecting you to the surgery? I cannot comment on the authenticity of the histopathology reports. If your operated specimen has been preserved, you can ask for it and approach another lab/hospital for a second opinion. Ovarian torsion and rupture is an emergency and can lead to gangrene and septicemia if not operated upon immediately. If both ovaries are removed it would lead to a premature surgical menopause due to lack of hormones produced by the ovaries. Lack of ovarian hormones is associated with various symptoms and complications and therefore removal of both ovaries in a premenopausal female is not advisable except under exceptional circumstances. The cyst in your left ovary was reported as benign. For your present condition you need further evaluation and investigations as I have previously suggested. I can understand that you have been through a lot of physical and mental anguish, but you need to stay strong and keep the faith. All the best and God Bless!
Comment by Dr. Monica, MD on Fri 08, May 2009 07:56am: Hi again, Thank you for your feedback amd your kind words. As for your present condition, it is difficult to make any conclusions without an examination and further investigations. It is possible that the cervical mass is cancerous but there may be other possibilities as well so I suggest that you undergo a thorough evaluation before discussing the treatment options. Take care and God Bless!
Comment by anghelson on Fri 08, May 2009 09:14pm: again thank you very much for your opinion. what steps do you think i should do. are there blood test that could determine if its cancer. again thank you very much
Comment by Dr. Monica, MD on Sat 09, May 2009 06:46am: Hi, A diagnosis of cancer can only be established or ruled out by taking a biopsy or an FNAC from the cervical mass. You need to get the blood tests done to determine your hemoglobin levels, your platelet counts etc. Please consult an oncologist or a gynecologist for a proper examination and further investigations as I have outlined previously. All the Best!

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