I am wondering if I should be getting a biospy and what are the chances that I have cancer?

Hi! Many thanks for your question on the forum and a warm welcome on board. I am so sorry to hear about all that you have gone through. Swollen lymph nodes across multiple areas or generalized lymphadenopathy can be due to viral infections such as mono or EBV or cytomegalovirus or due to bacterial infections like TB. HIV or AIDS, leukemia, lymphomas and other cancers can also be a cause. This could also be due to inflammatory conditions such as rheumatoid arthritis and Crohn’s (likely as you have diarrhea and anemia). With your medical history possibility of cancer will always remain and hence a more aggressive approach towards diagnosis should be adopted. Since CBC is normal, a peripheral blood smear should be done to look for abnormal or precursor cells. Montoux test for TB should be done and blood tests to detect infectious mononucleosis. RA factor should be tested and so also ANA or antinuclear antibodies. Stool should be tested for parasites, worms and infection. Before biopsy, a non invasive test like CT scan of a lymphnode from each site should be done. If nothing comes up, then biopsy should be done. Do discuss this with your PCP and get a referral for an oncologist to get a more clear picture. Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!