Bone marrow biopsy shows: (...a white count of 7.2 hemoglobin 12.2 MCV 86
platelet count 185 and approximate differential of 50% neutrophils 40%
lymphocytes 5% monocytes. ..Aspirate smears are cellular, mixed and somewhat
variable in appearance with generally orderly maturation to the mycloid
erythrocytes erythroid series and I don't see obvious dysplastic features.
Megakaryocytes are present. There is a very prominent and focally dominant
lymphoid population which is composed of relatively small cells with slightly
irregular nuclear margins but not a lot of clear cut plasmacytoid features.
Iron is present in recently generous amounts without ringed sidcroblasts.
..bone biopsy shows a normocellular marrow and approximately 60% with obvious
lymphoid aggregates which generally in near the smear cytology with a few larger
admixed cells. Generally lymphoid infiltrates appear to be nodular rather than
diffusely through the marrow and a CD20 immunoperoxidase stain confirms this.
CD3138 shows more than normal numbers of plasma cells but I don't think enough
to promote this clearly to a lymphoplasmacytic lymphoma/Waldenstrom's. Flow
cytometry shows a kappa light chain restricted B cell population within the
relatively small identified lymphocyte population which shows no significant
CD5, CD23 or CD10 coexpression. Plasma cells are very few in number and not
specifically going to be able to light chain type.
What does this mean in layman's terms? What stage am I and how can I measure
progress with Rituxan? My IgM is 329 and one lab shows this to be out of normal
range (40-230) while another lab's normal range is 55 to 375. Should I consider
this the pretreatment level? Is blood pressure reading a good indicator of
blood hyperviscosity?