Home   Recent Questions   Ask Oncologist    Health Forums   Testimonials   FAQs


This question was answered on Wed 05, Jan 2011 02:39pm by bobby s, md

lymphoma


    
Asked by anthro28 (Male; 72; glaucoma in left eye. blood pressure 140/85 arthritis, general tiredness; Relevant drugs:blood pressure medication. ) on Wed 05, Jan 2011 12:55pm
Priced at $19.00

Bone marrow biopsy shows: (...a white count of 7.2 hemoglobin 12.2 MCV 86 platelet count 185 and approximate differential of 50% neutrophils 40% lymphocytes 5% monocytes. ..Aspirate smears are cellular, mixed and somewhat variable in appearance with generally orderly maturation to the mycloid erythrocytes erythroid series and I don't see obvious dysplastic features. Megakaryocytes are present. There is a very prominent and focally dominant lymphoid population which is composed of relatively small cells with slightly irregular nuclear margins but not a lot of clear cut plasmacytoid features. Iron is present in recently generous amounts without ringed sidcroblasts. ..bone biopsy shows a normocellular marrow and approximately 60% with obvious lymphoid aggregates which generally in near the smear cytology with a few larger admixed cells. Generally lymphoid infiltrates appear to be nodular rather than diffusely through the marrow and a CD20 immunoperoxidase stain confirms this. CD3138 shows more than normal numbers of plasma cells but I don't think enough to promote this clearly to a lymphoplasmacytic lymphoma/Waldenstrom's. Flow cytometry shows a kappa light chain restricted B cell population within the relatively small identified lymphocyte population which shows no significant CD5, CD23 or CD10 coexpression. Plasma cells are very few in number and not specifically going to be able to light chain type. What does this mean in layman's terms? What stage am I and how can I measure progress with Rituxan? My IgM is 329 and one lab shows this to be out of normal range (40-230) while another lab's normal range is 55 to 375. Should I consider this the pretreatment level? Is blood pressure reading a good indicator of blood hyperviscosity?

Actions: | Forward |
Answer


Name 

Email 

Security code
Enter the text as shown above


E-Mail me when someone replies to this post
Answer by bobby s, md  on Wed 05, Jan 2011 02:39pm:

Hello,
Your questions are: Q1. What does this mean in laymans terms. Well, the bone marrow biopsy has detected some abnormal ("lymphoid") cells. The protein CD20 is present on these abnormal cells. It is not very clear what exactly these cells are.
Q2. What stage am I and how can I measure my progress with Rituxan? Stage refers to amount of spread of the lymphoma to the different organs of the body like lymph nodes, liver, spleen, bone marrow etc. It is not possible for me to give a very exact stage because imaging results are not available. However, generally speaking, bone marrow involvement by lymphoma primarily present elsewhere indicates advanced disease. Rituxan is active against some CD20 positive diseases, and progress maybe measured by serial measurement of lymphoma lesions. If Rituxan is working well, it will lead to decrease in size of lesions.
Bllod pressure is not a good or reliable measure of blood viscosity. Based on the description of the one test (bone marrow biopsy) that you have provided, I am unable to reach a conclusion. It would have been much more helpful if you had provided additional background information. What were the symptoms? For how long were they present? What additional tests were done? Any tests done on lymph nodes? What was the peripheral blood test report?
Many types of lymphoma are considered fully curable. Please feel free to ask additional follow-up questions/clarifications. All the best, and God Bless!

If you find the site useful, please consider making a donation.  Click the button to donate.   

Please rate my answer (select the stars, no need to log in.)  

This question is open for comments.  Please share your opinion.

Comments


Name 

Email 

Security code
Enter the text as shown above


E-Mail me when someone replies to this post
Other cancer questions you might be interested in.
  1. hodgkins lymphoma: what is the risk of recurence?  (Answered) - Viewed 1689 times   A good friend of mine has been diagnosed with hodgkins lymphoma about 5 years ago. He seems to be doing fine right now. What is...
  2. Non-Hodgkin's lymphoma - CAT scan showed a prominent pancreatic tail adjacent the gastric fundus  (Answered) - Viewed 2910 times   I was diagnosed with B-cell non-Hodgkin's lymphoma status post splenectomy in 12/2006 and have had CAT scans every 4 months sinc...
  3. b cell - Malignant lymphoma diffuse large b cell found  (Answered) - Viewed 1162 times   they found malignant lymphoma diffuse large b cell in my dad body i like to know if you can tel me how bad it is . and thank you...
  4. Small lymphocytic lymphoma treatment - Any idea on IVC or conventional treatments.  (Answered) - Viewed 989 times   I was diagnosed w/small lymphocytic lymphoma 8/04; treated with Fludarabine & Rituxan from 12/05 - 5/06. Key symptoms are swolle...
  5. What next after radiotherapy? - Non hodgkins lymphoma: Radiation advises, any second opinion on this?  (Answered) - Viewed 978 times   I am a Zambian male cancer patient. I was first treated for Casenoma for which I was given Vynchristin, Sacosalphemide, metthatr...
  6. Non-Hodgkins Lymphoma nodular sclerosis - Enlarged nodes in groin and pelvic area   (Answered) - Viewed 1845 times   just diagnosed with nodular sclerosis non-hodgkins lymphoma. what exactly is this specific type of lymphoma, treatment options a...
  7. please help me find out what wrong with me - Got ten lymph glands for about 4 months  (Answered) - Viewed 1162 times   hello i have got about ten lymph glands up which they have been up for about 4 months now but i'm also really tired, my voice ha...
  8. RECENT DIAGNOSED 24ML LUMP IN LEFT BREAST - Am I a victim of HRT?  (Answered) - Viewed 1063 times   I am 63 this year and was menopausal at age 42. At this time my gynaecologist prescribed progesterone and oestrogen tablets whic...
  9. Geriatric oncologist and/or lymphoma specialist-MD - Geriatric oncologist and lymphoma specialists in Silver Spring  (Answered) - Viewed 774 times   Where would I find listings of geriatric oncologists and/or lymphoma specialists in the Silver Spring, Maryland area to treat n...
  10. Itching for two years without manifestation of symptoms  (Answered) - Viewed 2278 times   Hello Doctor. I am trying to stay positive about the itching but it has been going on so long and no one has been able to figur...
  11. Suffering with itchy burning skin since September 2006  (Answered) - Viewed 3682 times   Hello. I have a general question about lymphoma. I have been suffering with itchy burning skin all over my body since Septembe...

 
What users are searching right now on Ask an oncologist now:
testicle cancer     wwwaskanocologistnowcom     would20high20creatine20kinase20and20immunoglobuline20E20leavels20be20atrributed20to20having20B20cell20lymphoma     where20is20your20liver20located     what20is20the20name20or20type20of20lung20cancer20that20spreads20the20fastest20out20of20all20cancer     what20is20meant20by20having20an20abnormal20protein20band     what20is20immunoglobulin20A     what20is20a20igg20lambda20monoclonal20band     what20does20free20lambda20light20chain20mean     what20does20dimpling20in20the20brest20look20like     what20does20IgG20Kappa20monoclonal20protein20mean     what20is20mortality20rate20for20lung20cancer     what20is20a20right20iliac20chain20lymph20node     undetermined20ground20rt20upper20lobe20of20lung203020yr20smoker20bad20cough20and20sob     travel20restrictions20high20elevation     trace20monoclonal20protein     they20found20a20blood20vessel20about20120centimeter20in20my20left20lung20I20have20CT20scan20procedure20tomorrow20can20what20could20it20be     synovial     swollen20collar20bone     survival     staging20for20multiple20myeloma     spine20cancer     show20video20of20radical20mastectomy     roseola     red20small20bumps20on20my20stomac     radial20scar20breast     pth20related20peptide     pth20peptide     prostate20cancer20and20black20spot20ct20scan     preauricular20lymph20nodes     poorly20differentiated20invasive20ductal20adenocarcinoma     picture20of20pancreas     phpmanager     pepic     paw20paw20cell20reg     paraprotein     panceratic20stage20420cancer20with20legs20swelling     palpablemassbeneath     painless20knot20jawline     pain20on20swallowing     nonhodgkins20lymphoma20and20lambda20monoclonial20cells     no20i20am20asking20if20i20am20having20pain20on20my20right20side20above20my20waist20and20it20feels20like20a20lump2020what20can20it20be     multiple20myeloma20stages     multiple20liver20cysts2020red20palms20of20hands     mugus     metastatic20prostate20cancer20to20bone     metastatic20liver20cancer     mainstream     lymph20node20stage20420lung20cancer     lung20cancer20knot20on20side20of20neck     low20beta20globulin     liver20tets20abnormal20and20enlarged20lymph20nodes20in20groin     liver20cyst     lambda20monoclonal20immunoglobin20igg     lambda20monoclonal20immunoglobin20igg     is20it20common20to20have2020mutiple20small20cysts20in20the20breast     invasive20ductal20adenocarcinoma     intermediate20oncotype20score     inflamed     ihaveapainfullumpbehindmykneeithasgottenbigger     igm20kappa     igm20lambda     i20have20stage20420metastatis20breast20cancer20to20the20lung2020how20long20do20i20stay20on20herceptin     i20have20had20BAC20cancer20and20Adenomacarcinoma20left20upper20lobe20and20right20lower20lobe20been20removed20Oct202011what20are20my20survival20rate20or20cancer20reocourrence     hypoechoic20well20defined20masses20in20right20pericaval20region20majours20abput205020202720cms     how20long20with20treatment20can20a20person20live20with20extensive20small20cell20lung20cancer     how20is20lung20cancer20identified     hodgkins20disease     high20wbc20high20platelets     have20pelvic20pain20goin20for20mri20next20week20just20finished20breast20cancer20treatment20what20are20the20chances20it20is20cancer     gamma20region     free20light20chains     extreme20itching     enlarged20liver20lymph20nodes20with20metastatic20breast20cancer     elevated20free20kappa20light20chains     do20you20have20to20smoke20to20get20lung20cancer     details20on20lamba20band20and20kappa20band20positive     control     Stage 1b renal cell carcinoma     cancer20spread20to20femur20bone     bronchitis     breast20puckering2020lump20under20arm20pit     breast20bleeding20tumor     breast20cancer20staging20pt1c     enlarged peripancreatic lymph nodes     are     any20cancer20with20cold20like20symptoms     StageIIIMultipleMyelomaIgA     NON20PAINFULBUMP20ON20ARM     NON     MRI20bone20scan     Lambda20light20chain20myeloma20with20amyloidosis     Lambda20Light20chain20myeloma     IgG20lambcia20monoclonal     If20you20have20been20diagnosed20with20bile20duct20cancer20and20your20liver20is206020affected20what20is20the20prognosis     IFE20pattern20shows20an20IgG20type20lambda20monoclonal20protein     Howlongdoesittakeforcolonpolypstoformandturnc     Endometrial20mets     Canabenignmole     5year     

©2011 - Ask an oncologist now  |  All Rights Reserved
The site is not a replacement for professional medical opinion, examination, diagnosis or treatment. Always seek the advice of your medical doctor or other qualified health professional before starting any new treatment or making any changes to existing treatment. Do not delay seeking or disregard medical advice based on information written by any author on this site. No health questions and information on askanoncologistnow is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure or prevent any disease without the supervision of a medical doctor. Posts made to these forums express the views and opinions of the author, and not the administrators, moderators, or editorial staff and hence askanoncologistnow and its principals will accept no liabilities or responsibilities for the statements made.

Home | Terms & Conditions | Contact Us | Frequently Asked Questions | Disclaimer | Privacy Policy | Advertise with us
Stats