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This question was answered on Tue 25, Mar 2008 02:38pm by Dr Heinrik M, MD

treatment options and experimental drugs for prostate cancer non responding to hormonal treatment


    
Asked by user (Male ) on Mon 24, Mar 2008 11:54pm

hi, What are the main treatment options for prostate cancer once it is not responding to hormonal treatment? Is there some experimental drugs or clinical trials that you would recommend as an oncologist?

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Answer by Dr Heinrik M, MD  on Tue 25, Mar 2008 02:38pm:

Hi, Treatment for hormone refractory disease could consist of a second-line hormonal agent (such as ketoconazole with or without a steroid) or chemotherapy (preferably with docetaxel – as this drug has shown a survival benefit). A promising drug undergoing trial is satraplatin – you could explore enrollment in studies using this drug. In terms of trials though, it may be more productive to consult at a nearby cancer center (those that conduct trials are usually connected with schools/universities), in order to explore what options there are. As a rough guide, a phase III trial evaluates drugs in late stages of development (meaning the dose and the toxicity profile is more firmly established) hence, the benefit of participation and the risks would be clearer. Bear in mind though that enrollment only gives you the chance, it does not guarantee the chance that the experimental drug will be given to you. Patients under trial receive: current standard of care, standard of care with experimental drug, or experimental drug alone

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Follow up:

Clarification by bru61 on Tue 25, Mar 2008 02:54pm:
If you have failed all approved treatments for hormone refractory prostate cancer, what are the experimental
treatments available (in addition to satraplatin)?  

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